[Purposes] This paper analyzes the significance of WeChat dissemination of academic journals and identifies the differences of influence factors at each level in order to explain how to operate an academic journal WeChat platform. [Methods] The description analysis, variance analysis, multiple linear regression analysis are used based on a large number of samples to identify the influence factors of WeChat dissemination of academic journals. [Findings] The WeChat content publication time,sequence and type all have significant impacts on communication effect,and there are significant differences between influence factors at each level. Publication in the evening has the most significant impacton the communication effect;the more backward the publishing sequence is,the worse the communication effect is. The original content in the new form of media editing is disseminated with the best effect, followed by the reprint contents. [Conclusions] The WeChat platform operation should pay attention to its publication time,sequence and type when releasing contents.